Mackenzie, Missouri is an unincorporated community located in South St. Louis County, about 20 minutes southwest of Downtown St. Louis in the 63123 Zip Code area. In 2018 the Village of Mackenzie voted to dissolve to become unincorporated. The community consists of three streets, Rhodes Drive, Holly Hills Avenue and Menola Street and lies along Mackenzie Road. The residents of Mackenzie are served by the Affton School District.